Neurological Associate Pain Management Center

Vero Beach, Florida

Hereditary Aspects of CRPS

Doctor Hooshmand and I have co-authored the following article: Hereditary Aspects of CRPS.

Below is an abstract from the article: Hereditary Aspects of CRPS.

Please click on the link below to view the full text of this article in PDF-format

Hereditary Aspects of CRPS-I



Hooshang Hooshmand, M.D. (Retired), and Eric M. Phillips and


Abstract: In a study of 824 complex regional pain syndrome(CRPS) patients treated in our clinic from January 1991 through January 1996, four cases suffering from Ehlers-Danlos syndrome(EDS) were ultimately diagnosed with CRPS (1). Since our report on 824 CRPS patients, we had an additional case referred to our clinic. This case involved twin sisters suffering from EDS-type III (hypermobility type) also diagnosed with CRPS. This additional case gave us five EDS/CRPS cases (six patients) which included two families having other members with both EDS/CRPS.

In our research we have also found five other cases (12 patients) suffering from other diseases such as Fabry' disease(FD), Sjogren's syndrome and lupus erythematosus (LE) that have contributed to these patients developing CRPS.

Over the years there have been very few published reports that have shown the hereditary aspects of CRPS associated with EDS and other diseases. In this article, we will discuss the hereditary aspects of CRPS.

Keywords: Complex regional pain syndrome(CRPS), Ehlers-Danlos syndrome(EDS), Familiar CRPS

(f-CRPS), Hereditary aspects, Hypermobility.